Doing that has not hurt my systems. I am a micro-scale experimenter and can easily leave a big percentage of a batch of concentrate in the system. I disconnect between pump and 5 micron filter and either blow in compressed air or attach concentrate outlet to a vacuum. Vacuum seems to work a little better. I can get a 20 oz soaked 5 mic down to 10 oz using a 110 VAC. -28" Hg capable, double diaphragm pump. Nominal weight of the 5 mic is 5 oz dry so I am still leaving some.